S100A11 and neoplasm: To further investigate the underlying mechanisms of the pro-tumour effect of exosomal S100A11, RNA sequencing was performed on the 4T1 cells co-cultured with M0 (M0-4T1), M2 (M2-4T1) or LAP-competent macrophages (LAP-M-4T1) and protein mass spectrometry (MS) was performed to detect proteins bound to S100A11 in 4T1 cells via immunoprecipitation (IP).