APP and Alzheimer disease: Marie-Claude Potier (France) interrogated the role of increased levels of APP (Amyloid Precursor Protein) in morphological aberrations in the endosomal compartment through the comparison of cortical pyramidal neurons obtained from postmortem brains of individuals with sporadic Alzheimer’s disease (AD), DS, and rare familial cases of AD [due to genomic duplication of the APP locus (APPdup)], as well as dermal fibroblasts derived from AD patients.