In summary, the LEGACy study underscored significant biological distinctions between European and LATAM patients with gastric and GEJ cancer:Distribution of molecular subtypes: our results suggest a deviation from TCGA results, notably showing a decreased proportion of CIN and HER2-positive cases, and an overrepresentation of GS tumors, in LATAM. Here, ERBB2 is linked to cervical squamous intraepithelial neoplasia.