By categorizing cases into two molecular groups based on their immunogenicity (immune: MSI/EBV vs. non-immune: GS/CIN), cases classified within the immune subtype demonstrated significant associations with distinct features, including lymphoid-rich stroma/solid morphological phenotype, higher frequency of PD-L1 expression, increased proliferative activity, reduced signet-ring cell (SRC) component, and elevated levels of CD8-positive immune cells (Supplementary Table 3). This evidence concerns the gene CD274 and cervical squamous intraepithelial neoplasia.