After 48 h of treatment, macrophages cultured with serum derived from patients with BC had lower CTH expression (P = 0.0135, Figure 1I; Figure S1D, Supporting Information) and higher CD206 expression (P = 0.0035, Figure 1I; Figure S1D, Supporting Information) than those cultured with serum derived from healthy donors. The gene discussed is MRC1; the disease is breast cancer.