A relationship between CART and AF components has been reported, since inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and IL-10, were found in AF; in addition, no association between these cytokines and adverse events, such as fever, was seen [11]. The gene discussed is TNF; the disease is atrial fibrillation.