Besides, our comparative analysis revealed that CRC tumor tissues with larger tumor size (P < 0.01, Fig. 1H), vascular invasion (P < 0.05, Fig. 1I), nerve invasion (P < 0.05, Fig. 1J) and positive serum CEA level (P < 0.001, Fig. 1K) showed higher ALDOA protein levels compared with their control counterparts, respectively. The gene discussed is ALDOA; the disease is neoplasm.