In sex-specific gene-based analysis, several genes in the APOE region (APOC1 TOMM40, PVRL2) were significant for all three AD neuropathology traits for both sexes, while the SGCZ gene was significant in female specific ncAD only (Fig. 3B, D, F, Supplementary Figure S1B, S1D, S1F). The gene discussed is APOE; the disease is Alzheimer disease.