SOD1 and ischemic stroke: We showed that high accumulation of Fe2+ in the brain of I/R-injured rats resulted in an imbalance of the antioxidant system, whereas EA treatment remarkably declined MDA levels, elevated SOD activity, and lessened ROS content, pointing to a striking amelioration of intracerebral lipid peroxidation and curtailing of ferroptosis, and that suppressing the origin and progression of cellular ferroptosis might be an equally valuable target for the exploration of novel therapeutic approaches for ischemic stroke in the future.