CRP increase (100% of patients, median 212 mg/l), increased PMN counts [n = 26, 74% of patients, including 20 (57%) and 6 (17%) patients with leukemoid reactions and PMN counts over 10 and 20 G/L, respectively], thrombocytosis [n = 17 (48%)], and inflammatory anemia [n = 33 (94%)] (Table 1 and Figure 1). This evidence concerns the gene CRP and thrombocytosis disease.