Cancers causing IL-6-mediated PIS are often hematological malignancies, lymphoma, or multiple myeloma.22, 23, 24 Many different solid cancers are also associated with PIS: renal cell carcinomas,1,4,6 lung cancers,1,2 sarcomas,1,7,10 and others.1 This evidence concerns the gene IL6 and hereditary clear cell renal cell carcinoma.