GJB3 causes delayed high-frequency phonological HL in an autosomal dominant manner; however, the pathogenesis of HL caused by these mutations remains unknown.21, 30 We noted 17 heterozygous mutation of c.538C>T and 8 heterozygous c.547G>A in the GJB3 gene, which is not very common. The gene discussed is GJB3; the disease is Hodgkins lymphoma.