rs1903858 (G/A) and its specific association with colon, rectal, or CRC is still being researched, it has been implicated in cancer susceptibility in various populations.39 Located in the promoter region of PTEN, some studies suggest rs2735343 plays a role in both colon and rectal cancers through its impact on PTEN expression.40 This evidence concerns the gene PTEN and rectal cancer.