PTEN and colorectal carcinoma: Our analyses demonstrated that CRC risk was associated with rs701848 in the C/C genotype and with rs2735343 in the GG and C/G genotypes and shown that these genotypes increased the risk of CRC in the Pashtun population which supports previous findings by Jang et al. 37 The distribution of genotypes or alleles in cases at both genetic sites of PTEN was statistically different from those in controls.