The HMC was mainly related to immunity and inflammation (Th17 cell differentiation, T cell receptor signalling, cytokine–cytokine receptor interactions, nuclear factor‐kappa B (NF‐κB) signalling, natural killer cell‐mediated cytotoxicity, neutrophil extracellular trap formation), microbial infections (Yersinia infection and coronavirus disease—COVID‐19) and tumour‐related signalling (phosphatidylinositol 3‐kinase‐protein kinase B (Akt) signalling; Figure 5C,D). Here, NFKB1 is linked to neoplasm.