Through Spearman correlation analysis, we integrated predominant immune feature data into the iEN model, which, after multiple iterations, resulted in the establishment of three disease models: AD/HC (AUC: 0.78AD/HCmodel vs. 0.62p‐tau181 vs. 0.52NFL vs. 0.6p‐tau181+NFL), DLB/HC (AUC: 0.86DLB/HCmodel vs. 0.58p‐tau181 vs. 0.46NFL vs. 0.58p‐tau181+NFL), and AD/DLB (AUC: 0.86AD/DLBmodel vs. 0.55p‐tau181 vs. 0.56NFL vs. 0.58p‐tau181+NFL). This evidence concerns the gene NEFL and Alzheimer disease.