Among CD8+ TEMRA cells, the T11 subgroup was significantly lower in AD compared to HC (p = 0.029), characterized by (CD27‐CD56‐CD11b+) phenotype, the T10 subgroup showed a downward trend (p = 0.077), and its characteristics were (CD27− CD56+ CD11b dim). Here, ITGAM is linked to Alzheimer disease.