Eleven most divergent immune features were identified in the DLB/HC model, including M03CD3, M01 IKBa, NK02IL_17A, T03CD45RA, M02CD184 (CXCR4), T14IL_17A, T16, T07CD45RA, T06CD45RA, T08FoxP3, and T17CD45RA, of which only T16 represented an immune subgroup and the rest were expressions of markers across different subgroups. The gene discussed is CXCR4; the disease is Lewy body dementia.