BEST1 and autosomal recessive bestrophinopathy: A suitablemodel is the Bestrophin channels, a family of calcium-activated Cl– channels (CaCCs) where many questions still remain.33,34 Four paralogs (Best1–4) have been identified in eukaryotes,which are responsible for a diverse range of functions.34 The best-known physiological role of Best1 isin the eye, where disease-causing mutations lead to retinal degenerativedisorders called bestrophinopathies.