SPP1 and enthesitis-related juvenile idiopathic arthritis: To assess the ameliorating effect of MO against Era-induced VSMC dysfunction, the protein expression of αSMA, calponin-1, SM22α, and OPN, as well as the mRNA expression of smooth muscle myosin heavy chain (SM-MHC), αSMA, and calponin-1 were estimated in Era-induced A7r5 cells (Fig. 7C–E).