ITGA2B and dengue disease: Hottz et al. (2013) reported high levels of CD41+ IL-1β+ platelets in patients diagnosed with DF/SD and isolated CD41+ IL-1β+ MPs (from clinical samples and from DENV-2 16,881-stimulated platelets in vitro), with increased levels of the NLRP3 inflammasome and caspase-1 activity.