Our experimental results indicate that both high and low doses of WMW feeding can reverse the reduction in UCP1, PGC-1α, CIDEA, and Elovl3 expression in the white adipose tissue of HFD-fed mice, suggesting that WMW can increase the browning of white adipose tissue in obese mice, thereby achieving the effect of treating obesity. This evidence concerns the gene PPARGC1A and obesity disorder.