PPARGC1A and obesity due to melanocortin 4 receptor deficiency: Our experimental results indicate that both high and low doses of WMW feeding can reverse the reduction in UCP1, PGC-1α, CIDEA, and Elovl3 expression in the white adipose tissue of HFD-fed mice, suggesting that WMW can increase the browning of white adipose tissue in obese mice, thereby achieving the effect of treating obesity.