ACHE and Alzheimer disease: A similar level of overlap was found with Phase 3 drugs (n = 15; Supplementary Fig. 12E), with neurotransmitter receptor candidates such as Donepezil, an acetylcholinesterase (AChE) inhibitor that helps remedy loss of functioning cholinergic neurons and improves cognitive decline in AD patients [143] (Supplementary Fig. 12F).