CYP3A5 and central nervous system cancer: Notably, CYP3A5 expression escalates with increasing the WHO grades of glioma, as supported by the results of immunohistochemical (IHC) staining of the glioma tissue microarray, as well as the mRNA expression data from TCGA glioma and glioma samples of our center (Fig. 2B-C, S3F).