KEAP1 and neurodegenerative disease: Currently, most studies on ferroptosis focus on malignant tumors and degenerative diseases, with mechanistic studies primarily focusing on abnormalities in iron metabolism, lipid peroxidation, and the Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2-related factor 2 (Nrf2) pathway (Liang et al. 2022; Park et al. 2021; Li et al. 2021).