In summary, our findings presented that the miR-335-3p was decreased during the fibrosis of LF cells, which further promoted the SERPINE2 expression, and then activated the β-catenin signaling pathway to stimulate the transcription of fibrosis-related genes (ACTA2 and COL3A1) to promote the fibrosis of LF cells (Fig. 5G). Here, ACTA2 is linked to Lassa fever.