In order to expolore the anti-cancer activity of L-1 by targeting EGFR mutant, we treated lung cancer cells with L-1 and unexpectedly found that L-1 significantly inhibited PC9 and H1975 (with EGFR mutant) cell proliferation, while not have effect on H460 and H1299 (with EGFR wild type) cell proliferation (Fig. 7a). This evidence concerns the gene EGFR and lung carcinoma.