SFRP4 and type 2 diabetes mellitus: In addition to the effects beyond weight loss of semaglutide on proteins related to CVD (as discussed above), other significantly regulated proteins in this analysis have previously been implicated in other conditions such as Alzheimer’s disease (TNC58, granulin59,60), T2D (sFRP4 (refs. 61,62)) and metabolic-associated steatohepatitis (LFABP63).