Strikingly, immunofluorescence staining of tumor sections showed an increase in the number of CD8+T cells in the papaverine-treated tumor compared to the vehicle-treated control tumor; GLUT1 staining, a HIF1 and hypoxia marker, further supported decreases in hypoxic regions in the papaverine-treated group (Fig. 1F,G). The gene discussed is HIF1A; the disease is neoplasm.