Several recent studies support the importance of autophagy in regulating MHC I, including the inhibition of basal autophagy in pancreatic ductal adenocarcinoma cells which restores MHC I cell surface expression and increases tumor infiltration of CD8+T cells in mice (Yamamoto et al, 2020; Münz, 2021; Kong et al, 2023). This evidence concerns the gene CD8A and pancreatic ductal adenocarcinoma.