MR analysis further revealed causal relationships for eight key genes corresponding to eQTL‐positive outcomes (p < 0.05): CDC25B (OR = 0.93; 95%CI = 0.87–0.99; p = 0.04), DNMT1 (0.66; 0.45–0.95; p = 0.03), GZMA (0.85; 0.75–0.97; p = 0.01), MTX1 (0.76; 0.63–0.92; p < 0.01), and SSH2 (0.87; 0.81–0.93; p < 0.01) may be associated with a lower risk of epilepsy, while FGD3 (1.19; 1.10–1.03; p < 0.01), RAF1 (1.24; 1.06–1.46; p < 0.01), and SH3BP5L (1.12; 1.00–1.24; p = 0.04) with a higher risk (Figure 2A). Here, SSH2 is linked to epilepsy.