GLIS2 and ZBTB5, poorly characterized TFs, are implicated in processes like epithelial–mesenchymal transition and nephronophthisis but not in the NF-κB system (Attanasio et al, 2007; Cheng et al, 2021b; de Dieuleveult and Miotto, 2018; Wilson et al, 2021). The gene discussed is GLIS2; the disease is nephronophthisis.