ZIC1 and medulloblastoma: Overexpression of G4 medulloblastoma ZIC1 mutant constructs in G3 medulloblastoma cell lines leads to tenfold fewer upregulated genes, as compared to WT ZIC1, whereas overexpression of the SHH medulloblastoma ZIC1 mutant constructs resulted in more differentially expressed genes as compared to WT controls (Fig. 7i,j and Extended Data Fig. 7a–c).