ZIC1 and medulloblastoma: Consistent with our hypothesis, cell proliferation assays in D425 and cell competition assays in D283 demonstrated a reduced antiproliferative effect for the G4 medulloblastoma ZIC1 mutants compared to the wild-type (WT) ZIC1, whereas SHH medulloblastoma ZIC1 mutants exhibited even more profound growth repression (Fig. 7b–d).