To test this hypothesis, we generated ZIC1 expression constructs with mutations from G4 medulloblastoma (G4 medulloblastoma ZIC1 mutants) in the zinc finger regions or with mutations from SHH medulloblastoma (SHH medulloblastoma ZIC1 mutants) in the carboxy terminus IDR (Fig. 7a). The gene discussed is ZIC1; the disease is medulloblastoma.