Regarding the diagnostic performance of AFP as a discriminating marker for HCC versus cirrhotic populations, ROC curve data analysis showed low validity AUC = 0.6 (95% CI, 0.524 — 0.770) with 60% sensitivity, 67% specificity, a positive predictive value of 64%, and a negative predictive value of 62% at a cutoff value of 7 ng/dl (Table 6; Fig. 4). Here, AFP is linked to hepatocellular carcinoma.