PV interneurons have been implicated in psychiatric disorders (Gonzalez-Burgos et al., 2015; Ferguson and Gao, 2018; Lauber et al., 2018; Nahar et al., 2021), and similar effects of FXR1 on PV interneuron EPSPs in other parts of the cortex could be relevant to the effects of FXR1 cKO on behavior (Shen et al., 2021) as well as FXR1-linked psychiatric conditions (Schizophrenia Working Group of the Psychiatric Genomics, 2014; Shen et al., 2021). Here, FXR1 is linked to psychiatric disorder.