CFH and age-related macular degeneration: Here, we aimed to create and evaluate iPSC-RPE models of patients with AMD with highly penetrant CFH variants: CFH c.607-610dupCCAA (p.Lys204Thrfs∗26), CFH c.550del (p.Ile184Leufs∗33), CFH c.524G>A (p.Arg175Gln), hereafter referred to as Lys204fsX, Ile184fsX, and Arg175Gln.