Within non–optic neuritis (ON) presentations, patients with MOGAD (n = 43) displayed higher median (interquartile range [IQR]) baseline values of IL6 (2.40 pg/mL [1.42–6.60] vs 1.54 [1.21–2.46], p = 0.036), IL8 (18.5 [10.7–52.8] vs 10.3 [7.89–15.3], p = 0.012), and IL18 (161 [125–258] vs 120 [101–166], p = 0.026) compared with patients with MS (n = 19) (Figure 1). This evidence concerns the gene IL18 and optic neuritis.