PDLIM7 and cancer: This process of LMP has also been observed in pathological conditions such as cancers, where lysosome-dependent cell death depends on release of lysosomal hydrolases from perforated lysosomes (24, 25) and pathological conditions such as alpha-synuclein aggregation (26) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration (27), suggesting its relevance to neurodegenerative disorders such as Parkinson’s disease.