LAMP1 and cancer: Several lines of evidence suggest that LAMP1 overexpression could dampen the effect of LMP agents such as LLOMe and GPN: Reduction in LAMP1 and LAMP2 expression sensitizes cancer cells to lysosomal photo-oxidation–mediated permeabilization (24), LAMP1 is known to bind to cholesterol (albeit less strongly than LAMP2) and to accept cholesterol from the luminal cholesterol scavenging protein Niemann-Pick intracellular cholesterol transporter 2 (41), where cholesterol is then found on the lysosomal limiting membrane during export.