Although the two databases for the mean European MAF values are somewhat different (especially in the cases of RAVER1 and MUC5B), these data together indicate that individuals carrying the minor variants of IFNAR2 rs2236757, LZTFL1 rs73064425, RAVER1 rs74956615 and ATP2B4 haplotype1-rs1541252, may be generally more susceptible to hospitalization-requiring COVID-19 than the general population. The gene discussed is MUC5B; the disease is COVID-19.