Regarding the hospitalized COVID-19 patients, higher minor allele frequencies (MAF) of the IFNAR2 rs2236757 (OR 1.33), LZTFL1 rs73064425, (OR 2.04–2.11), RAVER1 rs74956615 (OR 1.7–2.4), and potentially MUC5B rs35705950 (OR regarding the ALFA database 2.85) significantly correlated with greater COVID-19 disease susceptibility. The gene discussed is LZTFL1; the disease is COVID-19.