While studies observed decreased expression of non-mitophagy-related FKBPs in AD brains such as FKBP12 and FKBP52 [23, 24], the role of FKBP8 in AD remains unclear, and the impact of pTau on FKBP8-mediated mitophagy is unexplored. This evidence concerns the gene FKBP1A and Alzheimer disease.