(2006)[112] discovered that N. meningitidis lgtB R‐LPS, expressing a GlcNAc(β1‐3)‐Gal(β1‐4)‐Glc outer core is targeted by DC‐SIGN thereby causing increased bacterial uptake by DCs and skew of the immune response into a TH1 direction.[112] Overall these findings point out the urgent need for a comprehensive understanding of the interaction(s) between DC‐SIGN and the diverse LPS structures within our body; once again shedding light on this is crucial for the development of efficacious drugs and immunostimulant therapies against bacterial infections and immune‐mediated diseases. This evidence concerns the gene CD209 and bacterial infectious disease.