The chemerin receptors chemokine-like receptor 1 (CMKLR1) and G protein-coupled receptor 1 (GPR1), play crucial roles in regulating obesity, inflammation, and cancer, highlighting their potential as therapeutic targets (Bozaoglu et al., 2007; Ernst and Sinal, 2010; Su et al., 2021). Here, CMKLR1 is linked to obesity due to melanocortin 4 receptor deficiency.