We crossed stem cell-specific Lgr5-EGFP-IRES-creERT2 knock-in mice with Apcflox/flox mice (Lgr5CreERT2 Apcfl/fl mice); in the resulting mice, the transformation of Lgr5–GFP positive stem cells efficiently drives adenoma formation throughout the intestine after Apc loss induced by Cre activation using tamoxifen (Figure 7A). Here, LGR5 is linked to adenoma.