Inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- 1β (IL-1β), and interleukin-6 (IL-6) exacerbate APP expression, Aβ42 generation, neuronal destruction, (Buxbaum et al. 1992; Blasko et al. 2000; Rubio-Perez and Morillas-Ruiz 2012) as well as degeneration of the cholinergic basal forebrain cells and promotion of AchE activity, leading to Ach degradation with subsequent cognitive decline (Akiyama et al. 2000). This evidence concerns the gene TNF and Mental deterioration.