APP and Mental deterioration: Inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- 1β (IL-1β), and interleukin-6 (IL-6) exacerbate APP expression, Aβ42 generation, neuronal destruction, (Buxbaum et al. 1992; Blasko et al. 2000; Rubio-Perez and Morillas-Ruiz 2012) as well as degeneration of the cholinergic basal forebrain cells and promotion of AchE activity, leading to Ach degradation with subsequent cognitive decline (Akiyama et al. 2000).