POMC and obesity due to melanocortin 4 receptor deficiency: However, there have been reports of sexual dimorphism in mice with targeted deletion of miR17 ~ 92 in proopiomelanocortin-expressing neurons in the hypothalamus in the phenotype of aggravation of fatty diet-induced obesity only in male mutants and yielded sex-related differential gene expression profiles in responsive to high-fat diet between male and female neurons [27].