HRAS and head and neck squamous cell carcinoma: Following the example of Hoover et al. [7], we aimed at mimicking HPV-positive HNSCC by overexpressing the HPV16-oncogenes E6 and E7 in primary oral epithelial cells (POEC) combined with a constitutively active form of H-Ras (H-RasV12/S35) since this pathway is often enhanced in HNSCC (Fig. 1a) [4, 10].