In contrast, the primary tumor of GB1 showed lower ICAs in immune-gene Clusters 3 (leukocyte migration), 4 (humoral response and lymphocytes), and 8 (negative regulation of T-cell reactivation, PD-L1) when compared to tumor recurrences (reGB1 L1 and L2), suggesting adaptive immune responses in recurrent TiME samples. Here, CD274 is linked to neoplasm.