High expression of HLA-DR+ (p = 0.027), CD8+/LAG3+ (p = 0.039), CD8+/CTLA+ (p = 0.039), but not CD163+/PDL1+ (p = 0.12) were significantly associated with TTP (Fig. 1). Here, LAG3 is linked to thrombotic thrombocytopenic purpura.