LAG3 and neoplasm: LAG-3 positivity was significantly correlated with a higher ORR of 70.6% compared to 33.3% in the LAG-3-negative group (P = 0.029, Fig. 3A), a numerically higher long-term DCR of 88.2% vs. 70.3% (P = 0.271), and a greater mean percentage of tumor shrinkage (−48.7% vs. −23.6%, P = 0.014).