Associations between CD163+ immune cells in the tumor nest of LNM and PFS and OS were significant in multivariable analyses (Table 3) (P = 0.006, HRPFS-adj: 0.361 95% CI: 0.176–0.743 and P = 0.003, HROS-adj: 0.286 95% CI: 0.127–0.645) as well as CD163 GEX of DM and PFS and OS (P = 0.019, HRPFS-adj: 2.551 95% CI: 1.164–5.589 and P = 0.036, HROS-adj: 2.424 95% CI: 1.061–5.537). This evidence concerns the gene CD163 and neoplasm.