Profiling of tumor-infiltrating T cells based on CCR7 and CD45RA markers that could detect T-cell differentiation [18] revealed that female patients had significantly fewer effector memory (EM)/CD8+ T cells (p = 0.0054) and significantly more naïve/CD8 + T cells and T-effector memory cells re-expressing CD45RA cells/CD8 + T cells (p = 0.0338 and p = 0.0084, respectively) (Supplementary Fig. 8 and Supplementary Table 10). This evidence concerns the gene CD8A and neoplasm.