Among glioma, the most frequent CNS tumor entity, mutations within canonical histones H3.1 (HIST1H3B/C), H3.2 (HIST2H3C) and non-canonical histone H3.3 (H3F3A) [7, 31] as well as BRAF are well-established markers routinely analyzed in tumor tissue. The gene discussed is BRAF; the disease is glioma.