Seventeen colorectal cancers harboring a V600E mutation also presented with additional, predicted pathogenic mutations in KRAS, NRAS, or NF1 (17/709, 2.40%), comprising 13 colorectal cancers with NF1-inactivating mutations and four with KRAS mutations (4/709, 0.71%, mostly G12D). Here, KRAS is linked to colorectal cancer.