Consistent with these regional differences in normal tissues, analysis of the S:CORT cohort, which contained sufficient atypical colorectal cancers with RNA data, showed significantly higher expression of EREG in class 3 BRAF-mutant tumors lacking additional Ras mutations compared with class 1 mutants (P < 0.005, Dunn test; Fig. 5B). Here, EREG is linked to colorectal cancer.