The univariate Cox regression model showed that high grade (G1-G2 vs. G3–G4, p = 0.006), large tumor diameter (≤ vs. > 7 cm, p = 0.001), non-organ-confined tumors (pT1-pT2 vs. pT3–pT4, p = 0.002), lymph node invasion (p = 0.001), distant metastasis (p = 0.001), high densities of CD68 +  cells (≥ P75 at tumor center, p = 0.001; and tumor margin, p = 0.03; and P50 at the tumor center, p = 0.006), and CD4 + FOXP3 +  cells (≥ P75 at the tumor center, p = 0.037) were associated with worse CSS. Here, CD4 is linked to neoplasm.