A study in 2022, conducted by Balasubramaniam, discovered a significant number of diabetic individuals with chronic periodontitis having possible chances of developing cognitive impairment.14Another study suggests that the risk of cognitive impairment may increase by high IL-6 levels.15This study aimed to explore the effects of antibiotic periodontal treatment on MCI risk through the changes in protein plasma from blood samples assessment in T2DM patients. Here, IL6 is linked to chronic periodontitis.