TFRC and glioblastoma: The increasedaccumulation of TfR-targeted lipoDiR in liver and spleen might bedue to the high TfR expression levels in liver and spleen.48 Likewise, the enhanced brain delivery of pH-PEGengagerTfR-decorated PEG-lipoDiR in intracranial GBM-bearingBALB/c nude mice is consistent with nontumor mice groups (Figure S10).